Table 2. Effect of silencing 1B3 targets with siRNA on several cell phenotypes.
| Target gene | Cell count (7) | Caspase 3/7 (7) | Cell Cycle (5) | Migration (3) | Senescence (3) |
|---|---|---|---|---|---|
| CCND1 | ✓✓✓ | ✘ | ✓✓ | - | - |
| KRAS | ✓✓ | ✘ | ✓ | ✓ | ✓✓ |
| MCL1 | ✘ | ✓✓✓ | ✘ | - | ✘ |
| STMN1 | ✓ | ✘ | ✓ | ✘ | - |
| YWHAZ | ✘ | ✘ | ✓ | - | - |
| CDK6 | ✘ | ✘ | ✓ | - | - |
✓ = phenocopies 1B3 effect in 1 cell line, ✓✓ = phenocopies the effect of 1B3 in 2 cell lines, ✓✓✓ = phenocopies the effect of 1B3 in 3 or more cell lines, ✘ = does not phenocopy 1B3 effect in any cell line tested, - was not tested in this assay. Numbers in brackets indicate the number of cell lines assessed for each phenotype.