Figure 5.

Chromatin Landscape Analysis

(A) Hierarchical clustering of all ATAC-seq peaks.

(B) Peak changes between states. OC, open to closed; CO, closed to open; OO, open to open.

(C) Heatmaps of differential ATAC-seq peaks.

(D) Heatmaps of ATAC-seq peaks from (C) in EpiLCs and EpiSCs derived from RGd2 ESCs.

(E) Histone modification patterns at ATAC-seq peaks.

(F) Genome browser screenshots of H3K4me3 and H3K27me3 distribution at Prdm1, Tfap2c, and Prdm14 loci.

(G) Volcano plot showing expression fold changes for genes associated with ATAC-seq peaks shared between FS cells and EpiSCs. Purple, upregulated in EpiSCs; blue, upregulated in FS cells.

(H) Transcription factor binding motif enrichments at ATAC-seq peaks.