Table 5:

Regions showing significant association between gray matter and brain age residual (regress out sex, age (center) and age (center) squared) voxel-wise (corrected for multiple comparisons) – this adjusted for sex, age (centered), and age (centered) squared. Region descriptions are based on AAL3 atlas. Negative values indicate that greater brain age is associated with lower gray matter density (no positive values). The cluster size and maximum t-value (representing the t-value for a regression) for the clusters as well as the location of the maximum are reported. Note that there are three significant clusters, however a cluster can have multiple labels, which are indented.

Description	Cluster Size (# Voxels)	t-value max	MNI coordinate (x, y, z)
Left ACC presubiculum	369	−6.5	−8, 44, 0
Right ACC presubiculum	263	−5.5	8, 50, 12
Left ACC subiculum	92	−5.9	−2, 30, −10
Right ACC subiciulum	65	−4.7	6, 34, −8
Left ACC supracallosal	275	−6.1	−6, 36, 24
Right ACC supracallosal	88	−4.7	10, 36, 16
Left Amygdala	194	−5.1	−22, 2, −18
Right Amygdala	175	−5.1	28, −6, −16
Right Angular Gyrus	271	−6.6	50, −70, 30
Left Calcarine Gyrus	456	−5.6	−10, −74, 16
Right Calcarine Gyrus	325	−5.3	22, −98, 0
Left Cerebellum IV/V	366	−5.7	−26, −42, −22
Right Cerebellum IV/V	399	−5.2	28, −34, −24
Left Cerebellum VI	913	−5.5	−30, −44, −24
Right Cerebellum VI	872	−5.3	30, −74, −18
Left Cerebellum Crus I	72	−4.9	−42, −64, −22
Right Cerebellum Crus I	196	−4.8	48, −66, −20
Left Middle Cingulate	249	−5.3	−6, 20, 34
Right Middle Cingulate	327	−5.3	8, 26, 34
Left Posterior Cingulate	150	−5	−8, −54, 32
Left Cuneus	144	−6.5	−2, −70, 26
Right Cuneus	233	−4.9	14, −92, 14
Left Inferior Frontal (Operculum)	156	−5.5	−50, 8, 28
Right Inferior Frontal (Operculum)	246	−5.3	48, 8, 28
Left Inferior Frontal (Orbital)	217	−5.8	−30, 36, −12
Right Inferior Frontal (Orbital)	159	−5.4	50, 46, −10
Left Inferior Frontal (Triangular)	274	−5.4	−42, 36, 24
Right Inferior Frontal (Triangular)	108	−5.1	46, 22, 0
Left Medial Frontal (Orbital)	567	−6.7	−10, 50, −6
Right Medial Frontal (Orbital)	445	−6.7	2, 48, −12
Left Middle Frontal	930	−6.3	−42, 42, 26
Right Middle Frontal	317	−5.7	32, 56, −12
Left Superior Frontal	855	−6.8	−22, 60, 6
Right Superior Frontal	380	−5.7	18, 44, 34
Left Medial Frontal (Superior)	561	−6.2	−8, 50, 18
Right Medial Frontal (Superior)	596	−6.7	8, 58, 6
Left Fusiform Gyrus	960	−7.5	−26, −36, −18
Right Fusiform Gyrus	1038	−5.5	30, −74, −16
Left Heschl Gyrus	93	−5.7	−38, −22, 4
Right Heschl Gyurs	124	−5.6	54, −4, 4
Left Hippocampus	345	−5.7	−26, −10, −18
Right Hippocampus	251	−5.3	22, −8, −20
Left Insula	932	−6.3	−36, −14, 16
Right Insula	975	−6.7	34, 16, 4
Left Lingual Gyrus	710	−6.7	−16, −56, −8
Right Lingual Gyrus	156	−5.3	2, −72, 2
Left Nucleus Accumbens	133	−5.7	−2, 6, −8
Left Inferior Occipital	129	−5.8	−48, −60, −18
Right Inferior Occipital	60	−4.9	48, −62, −14
Right Middle Occipital	418	−6.5	50, −70, 28
Right Superior Occipital	267	−5.5	30, −74, 40
Left Orbitofrontal Gyrus (anterior)	231	−6.1	−38, 40, −18
Right Orbitofrontal Gyrus (anterior)	237	−5.5	32, 48, −14
Left Orbitofrontal Gyrus (lateral)	133	−6.9	−38, 40, −16
Left Orbitofrontal Gyrus (medial)	279	−5.6	−20, 30, −24
Right Orbitofrontal Gyrus (medial)	259	−6.2	16, 22, −20
Left Orbitofrontal Gyrus (posterior)	330	−6.3	−22, 8, −22
Right Orbitofrontal Gyrus (posterior)	194	−5.6	26, 12, −20
Left Olfactory Gyrus	215	−6.3	−2, 6, −10
Right Olfactory Gyrus	166	−5.9	2, 22, −14
Left Parahippocampus	365	−6.4	−22, 8, −24
Right Parahiippocampus	528	−5.4	22, −8, −32
Left Postcentral Gyrus	578	−6.4	−46, −18, 40
Right Postcentral Gyrus	194	−5	56, −6, 38
Left Precentral Gyrus	389	−6.2	−52, −6, 28
Right Precentral Gyrus	508	−6	50, −10, 42
Left Precuneus	462	−6.4	−8, −54, 34
Right Precuneus	461	−5.8	8, −68, 32
Right Putamen	104	−5	30, 14, 4
Left Rectus Gyrus	626	−7.3	−2, 28, −18
Right Rectus Gyrus	544	−6.4	2, 34, −20
Left Rolandic Operculum	373	−6	−38, −16, 16
Right Rolandic Operculum	370	−6.7	52, 6, −2
Left Supramarginal Gyrus	92	−5.1	−44, −36, 24
Right Supramarginal Gyrus	187	−5.2	58, −26, 18
Left Inferior Temporal Gyrus	977	−6.1	−48, −58, −18
Right Inferior Temporal Gyrus	1238	−6.4	54, 4, −34
Left Middle Temporal Gyrus	1092	−7.1	−50, 4, −32
Right Middle Temporal Gyrus	1462	−7.1	62, −30, −2
Left Middle Temporal Pole	344	−7.8	−46, 10, −28
Right Middle Temporal Pole	604	−6.6	42, 14, −32
Left Superior Temporal Pole	639	−6.1	−22, 6, −22
Right Superior Temporal Pole	489	−6.6	42, 12, −30
Left Superior Temporal Gyrus	810	−6.6	−44, −36, 20
Right Superior Temporal Gyrus	874	−6.1	62, −32, 2
Cerebellum Vermis VIII	101	−4.2	6, −66, −36
Left Middle Occipital	388	−6	−30, −94, 8
Left Superior Occipital	170	−5.1	−20, −92, 24
Left Paracentral Lobule	141	−5.2	−14, −26, 76