Table 2.

List of down-regulated lncRNAs in CAD (HCAEC, human coronary endothelial cells; HUVEC, human umbilical vein endothelial cells).

LncRNA	Samples	Cell lines	Interactions	Signaling pathway	Association with clinical properties	Function	References
GAS5	Plasma samples from 30 CAD patients and 30 healthy controls	HCAECs	p-mTOR	mTOR pathway	–	Its down-regulation increases phosphorylated mTOR levels, but its up-regulation has reverse effects	(41)
GAS5	Serum samples from 102 CAD patients and 98 control subjects, 72 y Sprague–Dawley rats established as CAD model	–	–	Wnt/β-catenin signaling pathway	CK-MB, Troponin I, Gensini score	Inhibits apoptosis of cardiomyocyte, oxidative stress, and inflammatory damage in CAD rat models; reduces myocardial damages in these rats	(33)
NEXN-AS1	Atherosclerotic arterial samples from patients and normal individuals, blood samples from 113 CAD patients, 69 myocardial infarction, 40 heart failure, and 40 healthy subjects, ApoE−/− mice, NEXN+/− mice	THP-1, HUVECs, VSMCs	NEXN, BAZ1A	–	–	Interacts with BAZ1A and contributes to elevation of NEXN expression	(17)
ANRIL (DQ485454)		HCAECs, HUVECs	CLIP1, EZR, LYVE1	–	–	Its overexpression suppresses TEM process in monocyte migration of endothelial cells and adhesion of monocytes to endothelial cells	(16)
Chast	Blood samples from 50 premature CAD patients and 50 age- and gender-matched healthy volunteers as controls	–	–	–	FBS levels	May be implicated in CAD development	(18)
HULC	Blood samples from 50 premature CAD patients and 50 age- and gender-matched healthy volunteers as controls	–	–	–	Age, FBS, TG	Has diagnostic value for distinguishing CAD patients from healthy individuals	(18)
DICER1-AS1	Blood samples from 50 premature CAD patients and 50 age- and gender-matched healthy volunteers as controls	–	–	–	FBS levels, TG, TG/HDL ratio	Has diagnostic value for distinguishing CAD patients from healthy individuals	(18)
MEG3	40 CAD tissues and 35 control tissues	VSMC	miR-26a, Smad1	–	–	Its overexpression represses proliferation and induces apoptosis in VSMCs by targeting miR-26a and increasing expression of Smad1	(42)
MEG3	15 CAD tissues and 15 normal arterial tissues	HUVECs	miR-21, RhoB, PTEN	–	–	Its overexpression suppressed proliferation and migration through targeting miR-21 and regulation of RhoB and PTEN expression	(29)
lincRNA-p21	Blood samples from 12 CAD patients and 8 control subjects, ApoE−/− mice	HA-VSMC, RAW264.7	MDM2, p53	–	–	Regulates proliferation and apoptosis in vascular smooth muscle cell by interacting with MDM2 and modulation of p53 activity	(43)
CASC11	Plasma samples from 82 CAD patients and 82 age- and gender-matched healthy individuals	HCAECs	TGF-β1	–	Patients survival	Its overexpression reduces expression of TGF-β1 in HCAECs	(19)