Table 5.
LncRNAs polymorphisms and CAD.
| LncRNA | Polymorphism | Samples | Population | Assay method | Association | References |
|---|---|---|---|---|---|---|
| ANRIL | rs1330049, rs2383206, rs10757278, rs10757274 | Blood samples from 1,034 CAD patients and 1,034 healthy subjects | Asian Indians | TaqMan allelic discrimination assay | All of these SNPs were associated with CAD risk | (52) |
| ANRIL | rs2383207, rs1333049 | Blood samples from 550 CAD patients, 550 patients with ischemic stroke, and 550 healthy individuals | Han Chinese | Sequenom MassARRAY on an Agena platform | There was no association between theses SNPs and CAD predisposition | (56) |
| ANRIL | rs496892, rs7865618 | Blood samples from 100 patients with periodontitis (PD) and CAD and 100 healthy volunteers as controls | South Indian population | ARMS-PCR, PCR-RFLP | Both of these polymorphisms were associated with elevated risk of PD and CAD Also rs496892-rs7865618 A-G and rs496892-rs7865618 G-G haplotypes were associated with increased risk of PD and CAD |
(53) |
| ANRIL | rs564398, rs4977574, rs2891168, rs1333042 | Blood samples from 250 patients with CAD and 252 age-matched control subjects | Saudi Population | TaqMan assay | Distribution of these SNPs were different in CAD group and control group | (57) |
| ANRIL | rs1333040, rs1004638 | Blood samples from 200 patients with CAD 110 healthy subjects | Iranian | PCR-RFLP | There was no association between these SNPs and CAD susceptibility | (54) |
| H19 | rs2735971, rs3024270, rs2839698 | Blood samples from 366 CAD patients and 366 matched control individuals | Chinese | KASP platform | Genotypes of rs2735971 and rs3024270 were associated with reduced risk of CAD Also rs2735971-rs2839698-rs3024270 A-C-C haplotype was associated with decreased risk of CAD. |
(55) |
| H19 | rs217727, rs2067051 | Blood samples from 701 patients with CAD and 873 age- and gender-matched control individuals | Chinese | TaqMan real time PCR | A allele of rs2067051 was associated with reduced risk of CAD, but T allele of rs217727 was correlated with elevated CAD risk. | (58) |
| LINC00841 | rs1870634 | Blood samples from 155 patients with CAD and 112 age- and sex-matched subjects without CAD | Iranian | real-time PCR-HRM | GG genotype of rs1870634 was correlated with augmented risk of CAD | (59) |
| MALAT1 | rs619586 | Blood samples from 508 patients with CAD and 562 age-, sex-, and ethnicity-matched control individuals | Chinese | TaqMan allelic discrimination assay | G allele and AG/GG genotypes of rs619586 were associated with decreased risk of CAD | (60) |
| lincRNA-p21 | rs9380586, rs4713998, rs6930083, rs6931097 | Blood samples from 615 CAD patients and 655 control subjects | Han Chinese | PCR-LDR | rs9380586-rs4713998-rs6930083-rs6931097 G-A-A-G haplotype was associated with decreased CAD risk | (61) |
| SENCR | rs555172 | Blood samples from 150 CAD patients and 149 healthy controls | Iranian | ARMS-PCR | There was no association between rs555172 polymorphism and CAD predisposition | (62) |