Table 6.

List of up-regulated circRNAs in CAD.

CircRNAs	Samples	Assessed cell line	Gene/protein interaction	Association with clinical features	Function	References
Hsa_circ_0004104	Blood samples from 436 male patients with CAD 297 male control subjects	THP-1	–	HDL-C levels	Its up-regulation was implicated in CAD pathogenesis and dysregulates proatherosclerotic and antiatherosclerotic genes expression	(63)
circ-SATB2	–	VSMCs	STIM1	–	Regulates proliferation, migration, and apoptosis in VSMCs by up-regulating expression of STIM1	(65)
hsa_circ_0089378 hsa_circ_0083357 hsa_circ_0082824 hsa_circ_0068942 hsa_circ_0057576 hsa_circ_0054537 hsa_circ_0051172 hsa_circ_0032970 hsa_circ_0006323	651 CAD patients and 287 control subjects	–	hsa-miR-130a-3p	–	Theses circRNAs suppress expression of hsa-miR-130a-3p and thus up-regulate expression of TRPM3 in CAD patients	(64)
circ_RUSC2	–	VSMCs	SYK	–	Promotes migration and invasion of VSMCs by up-regulating SYK expression	(68)