Table 7.
List of down-regulated circRNAs in CAD.
CircRNAs | Samples | Assessed cell line | Association with clinical features | Function | References |
---|---|---|---|---|---|
circZNF609 | Blood samples from (peripheral blood leukocytes) 330 patients with CAD and 209 control individuals | RAW264.7 | C-reactive protein levels, lymphocyte counts | Its overexpression contributes to decreased expression of IL-6 and TNF-α and increased expression of IL-10 | (66) |
hsa_circ_0029589 | Blood samples (PBMCs) from 24 patients with clinical presentation of chest pain, 16 patients with stable angina, and 28 patients with acute coronary syndrome | – | – | Its overexpression decreased pyroptosis of macrophages | (67) |