Table 8.

Diagnostic Role of circRNAs in CAD.

CircRNAs	Expression pattern	Samples	ROC curve analysis			References
			Sensitivity	Specificity	AUC
Hsa_circ_0004104	Up-regulated	Blood samples from (PBMCs) 436 male patients with CAD 297 male control subjects	–	–	0.700	(70)
Hsa_circ_0001879	Up-regulated	Blood samples from (PBMCs) 436 male patients with CAD 297 male control subjects	–	–	0.703
Hsa_circ_0004104 Hsa_circ_0001879	Up-regulated Up-regulated	Blood samples from (PBMCs) 436 male patients with CAD 297 male control subjects	–	–	0.742
Hsa_circ_0004104 Hsa_circ_0001879 together with smoking, TC and serum creatinine	Up-regulated Up-regulated	Blood samples from (PBMCs) 436 male patients with CAD 297 male control subjects	–	–	0.832
Hsa_circ_0124644	Up-regulated	Blood samples from 179 CAD patients and 157 control individuals	0.861	0.626	0.769	(69)
Hsa_circ_0124644 along with smoking, hypertension, DM, LDL, and TC	Up-regulated	Blood samples from 179 CAD patients and 157 control individuals	0.759	0.704	0.804
Hsa_circ_0124644 Hsa_circ_0098964	Up-regulated Up-regulated	Blood samples from 179 CAD patients and 157 control individuals	0.825	0.730	0.811
Hsa_circ_0124644 Hsa_circ_0098964 along with smoking, hypertension, DM, LDL, and TC	Up-regulated Up-regulated	Blood samples from 179 CAD patients and 157 control individuals	0.832	0.696	0.843
hsa_circ_0005540	Up-regulated	Plasma exosomes 108 patients with CAD and 89 subjects without CAD	–	–	0.853	(71)
circ-YOD1	Up-regulated	Analysis of 7 CAD-related microarray datasets	–	–	0.824	(72)
circZNF609	Down-regulated	Blood samples from (peripheral blood leukocytes) 330 patients with CAD and 209 control individuals	–	–	0.761	(66)