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MK2 regulates the expression of Cxcl-12 in TAMs to promote angiogenesis and tumor progression. MK2 activity is required for expression of Cxcl-12 in tumor associated macrophages, and for Serpin-E1 expression within the tumor microenvironment, promoting tumor angiogenesis and progression. Mouse images courtesy of Clker/Barretto. Tumor angiogenesis, macrophages, and carcinoma images adapted from Servier Medical Art.
