Table 2.
HRs and 95% CIs for microvascular and macrovascular complications of type 2 diabetes according to pre-diagnosis BMI (categories and per 5 kg/m2)
| Diabetes complication | BMI category | Continuous BMI, per 5 kg/m2 (n = 1083) |
|||
|---|---|---|---|---|---|
| 18.5–24.9 kg/m2 (n = 99) |
25.0–29.9 kg/m2 (n = 452) |
30.0–34.9 kg/m2 (n = 377) |
≥35.0 kg/m2 (n = 155) |
||
| Total vascular complications | |||||
| No. of cases / person-years | 24 / 1073.9 | 159 / 4844.6 | 147 / 4047.2 | 66 / 1663.1 | 395 / 11,623.9 |
| Age- and sex-adjusted model | 1.00 (Ref.) | 1.28 (0.81, 2.00) | 1.51 (0.97, 2.36) | 1.86 (1.15, 3.01) | 1.17 (1.05, 1.30) |
| Model 2a | 1.00 (Ref.) | 1.29 (0.81, 2.04) | 1.57 (0.99, 2.50) | 1.97 (1.20, 3.24) | 1.18 (1.06, 1.31) |
| Model 3b | 1.00 (Ref.) | 1.23 (0.77, 1.98) | 1.51 (0.95, 2.42) | 2.05 (1.23, 3.41) | 1.19 (1.07, 1.34) |
| Macrovascular complications | |||||
| No. of cases / person-years | 7 / 1107.3 | 38 / 5204.7 | 32 / 4376.5 | 8 / 1831.9 | 85 / 12,516.7 |
| Age- and sex-adjusted model | 1.00 (Ref.) | 0.91 (0.39, 2.11) | 1.02 (0.44, 2.36) | 0.70 (0.24, 2.03) | 1.01 (0.78, 1.32) |
| Model 2a | 1.00 (Ref.) | 0.94 (0.40, 2.19) | 1.09 (0.45, 2.60) | 0.77 (0.26, 2.25) | 1.05 (0.81, 1.36) |
| Model 3b | 1.00 (Ref.) | 0.89 (0.38, 2.11) | 0.99 (0.41, 2.40) | 0.68 (0.23, 2.04) | 1.00 (0.76, 1.31) |
| Microvascular complications | |||||
| No. of cases / person-years | 19 / 1108.1 | 138 / 5082.4 | 129 / 4218.1 | 62 / 1707.6 | 347 / 12,122.7 |
| Age- and sex-adjusted model | 1.00 (Ref.) | 1.43 (0.86, 2.37) | 1.71 (1.04, 2.83) | 2.38 (1.39, 4.06) | 1.20 (1.07, 1.35) |
| Model 2a | 1.00 (Ref.) | 1.41 (0.84, 2.37) | 1.76 (1.06, 2.95) | 2.50 (1.44, 4.36) | 1.21 (1.07, 1.36) |
| Model 3b | 1.00 (Ref.) | 1.33 (0.78, 2.26) | 1.69 (1.00, 2.85) | 2.70 (1.53, 4.76) | 1.24 (1.09, 1.40) |
| Kidney disease | |||||
| No. of cases / person-years | 11 / 1130.1 | 74 / 5309.4 | 80 / 4386.7 | 42 / 1778.1 | 207 / 12,607.7 |
| Age- and sex-adjusted model | 1.00 (Ref.) | 1.42 (0.73, 2.75) | 2.01 (1.04, 3.87) | 3.10 (1.57, 6.13) | 1.38 (1.20, 1.58) |
| Model 2a | 1.00 (Ref.) | 1.45 (0.74, 2.82) | 2.09 (1.07, 4.07) | 3.36 (1.67, 6.79) | 1.39 (1.21, 1.60) |
| Model 3b | 1.00 (Ref.) | 1.37 (0.70, 2.70) | 2.02 (1.02, 3.97) | 3.57 (1.72, 7.41) | 1.42 (1.22, 1.66) |
| Neuropathy | |||||
| No. of cases / person-years | 10 / 1118.7 | 90 / 5250.6 | 75 / 4417.1 | 35 / 1794.0 | 211 / 12,591.1 |
| Age- and sex-adjusted model | 1.00 (Ref.) | 1.47 (0.75, 2.88) | 1.54 (0.79, 2.98) | 2.10 (1.03, 4.27) | 1.12 (0.96, 1.31) |
| Model 2a | 1.00 (Ref.) | 1.43 (0.71, 2.87) | 1.55 (0.78, 3.10) | 2.18 (1.05, 4.54) | 1.12 (0.96, 1.31) |
| Model 3b | 1.00 (Ref.) | 1.32 (0.66, 2.65) | 1.41 (0.71, 2.80) | 2.14 (1.04, 4.43) | 1.11 (0.94, 1.31) |
Table presents combined rounded values from the ten imputation datasets
aModel 2: age- and sex-adjusted model + education, smoking status, smoking duration, physical activity, alcohol consumption, MedPyr score, family history of diabetes, myocardial infarction and stroke
bModel 3: Model 2 + prevalent conditions of hypertension and dyslipidaemia