Table 4.
Association between tumor location (left/right-sided breast cancer) and carotid artery plaque score in breast cancer survivors
| Outcome | Left-sided breast cancer (n = 83) | Right-sided breast cancer (n = 89) |
Model I β (95% CI)a |
Model II β (95% CI)a |
|---|---|---|---|---|
| Carotid plaque score, median (IQR) | ||||
| Total | 2.0 (1.0–3.5) | 1.0 (0.0–3.0) | − 0.24 (− 0.56;0.09) | − 0.15 (− 0.36;0.05) |
| Left | 1.0 (0.0–2.0) | 1.0 (0.0–2.0) | − 0.34 (− 0.68;− 0.00) | − 0.31 (− 0.60;− 0.02) |
| Right | 1.0 (0.0–2.0) | 1.0 (0.0–2.0) | − 0.07 (− 0.43;0.29) | − 0.01 (− 0.36;0.35) |
| Intima-media thickness, mean (SD) | ||||
| Total | 0.85 (0.13) | 0.84 (0.15) | − 0.02 (− 0.05;0.02) | − 0.01 (− 0.05;0.03) |
| Left | 0.85 (0.15) | 0.84 (0.15) | − 0.02 (− 0.06;0.02) | − 0.01 (− 0.05;0.04) |
| Right | 0.84 (0.14) | 0.84 (0.17) | − 0.01 (− 0.06;0.03) | − 0.01 (− 0.06;0.03) |
| Cerebral blood flow, ml/min, mean (SD) | ||||
| Total | 507 (84) | 530 (92) | 26.2 (0.29;52.1) | 25.9 (− 0.90;52.7) |
| Brain perfusion, ml/min per 100 ml, mean (SD) | ||||
| Total | 56.0 (8.1) | 59.0 (9.4) | 3.2 (0.6;5.9) | 3.5 (0.7;6.2) |
Model I = adjusted for age and body mass index; Model II = as Model I, plus: systolic blood pressure, diastolic blood pressure, age at menopause, prevalence of diabetes, smoking status, use of antihypertensive medication, anticoagulant medication, and lipid-lowering medication, and education
CI confidence interval, IMT intima-media thickness, IQR interquartile range, SD standard deviation
aDifference in median total plaque score, mean intima-media thickness, mean total cerebral blood flow, or mean brain perfusion between breast cancer survivors treated with left-sided cancer (reference) and right-sided cancer