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. 2021 Jan 12;476(4):1751–1763. doi: 10.1007/s11010-020-04020-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Significant mRNA profile changes induced by circSlc7a11 in LLC-WRC 256 cells. Differentially expressed mRNAs in LLC-WRC 256 cells with altered circSlc7a11 expression were characterized by deep RNA sequencing. Hierarchical clustering was performed to analyze differentially expressed genes in circSlc7a11-overexpressing LLC-WRC 256 cells (a), as well as those transfected with si-circSlc7a11-1 (b), and si-circSlc7a11-2 (c). In total, 18 genes were differentially expressed in LLC-WRC 256 cells by either circSlc7a11 overexpression or silencing (d). Upregulated and downregulated expression are presented in red and green, respectively. NC: negative control