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. 2021 Jan 15;476(4):1797–1811. doi: 10.1007/s11010-020-04023-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Expression of muscle specific miRNAs during myogenesis. (a) The expression of miR-1 in C2C12 increased immediately after 24 hrs of differentiation (T1) ant it continued to raise progressively during differentiation (T5 and T10); the trend of miR-206 was similar to that of miR-1 even if it started to increase significantly at the intermediate stage (T5). The expression of miR-133a and miR-133b was quite similar since both showed an increase in the intermediate stage (T5) remaining stable in the late stage of myogenic differentiation (T10). (b) The expression profile of miRNA contained in the exosomes released in the culture medium showed a peak of expression starting from the intermediate step of differentiation (T5) and was maintained till T10, while miR-206 expression showed a less marked increase at the intermediate and late stage of differentiation. Data are representative of three experiments; they are expressed as mean ± SD and the level of significance was set at p < 0.05