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. 2021 Feb 23;9:610553. doi: 10.3389/fcell.2021.610553

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Copyright © 2021 Du, Li, Yang, Zeng, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of the NORFA-mediated protein–protein interaction network. The NORFA-mediated protein–protein interaction (PPI) network was constructed based on the DEmRNAs obtained from RNA-seq results. A total of 462 protein-coding DEmRNAs (nodes) were identified in the PPI network. Color scale depicts the expression pattern of DEmRNAs and ranges from blue to red (red indicates up-regulated and blue indicates down-regulated). Degrees are shown as the size of the nodes. The dotted areas indicate four significant modules (module I in orange, module II in red, module III in green, and module IV in blue). The most enriched signaling pathways (P < 0.05) represented by the four modules are depicted.