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Localization of the neuronal intracellular CLCs to distinct, yet overlapping compartments of the endosomal-lysosomal pathway. ClC-3/ClC-4 localize to various endosomal populations; ClC-6 to late endosomes where it partially overlaps with ClC-7/Ostm1, the only CLC on lysosomes. ClC-3 is to a minor extent additionally found on synaptic vesicles. The CLCs exchange 2Cl− for 1H+ and mediate the accumulation of luminal Cl- in the progressively acidified organelles.
