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. 2021 Feb 23;9:639231. doi: 10.3389/fcell.2021.639231

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Copyright © 2021 Bose, He and Stauber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of various (partially putative) components of the interconnected system of ensosomal/lysosomal ion homeostasis. CLC exchanger activity (here exemplary of ClC-7) directly affects the luminal pH and Cl⁻ concentration. These will affect the transmembrane voltage ΔΨ and concentrations of further ion species and hence osmolarity. The cartoon was created using Servier Medical Art templates (https://smart.servier.com) licensed under a Creative Commons License (https://creativecommons.org/licenses/by/3.0/). The figure was taken from Astaburuaga et al. (2019).