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. 2021 Feb 23;12:595140. doi: 10.3389/fimmu.2021.595140

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Copyright © 2021 Liu, Chu, Jiao, Zhou, Qi and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SFTSV infection induces the release of the pro-inflammatory cytokines interleukin-1β (IL-1β) in human PMBCs and C57/BL6 mice. (A, B) SFTSV viral RNA and β-actin mRNAs in human PBMCs were quantified by qPCR. (C, D) IL-1β and β-actin mRNAs in human PBMCs were quantified by qPCR. (E) Human PBMCs were infected with SFTSV at different MOIs (0.1, 0.5, 1, and 2) or treated with LPS. IL-1β levels were measured in the supernatants by enzyme-linked immunosorbent assay (ELISA). (F) SFTSV viral RNA and β-actin mRNAs in mice spleen were quantified by qPCR. (G) IL-1β and β-actin mRNAs in mice spleen were quantified by qPCR. (H) IL-1β levels in mice sera were determined by ELISA. Data are mean values ± SD derived from the samples collected in two times under identical conditions. *P<0.05, **P<0.01, ***P<0.001.