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. 2021 Feb 23;9:607142. doi: 10.3389/fcell.2021.607142

FIGURE 2.

FIGURE 2

Knockdown of C1QBP inhibits TNBC migration, invasion, and chemoresistance to paclitaxel in vitro. (A) Knockdown of C1QBP was confirmed using real-time qPCR and western blot after Hs578T cells were transfected with siRNA. (B) Migration and invasion analysis indicates differential cell motilities in Hs578T cells. (C) The knockdown efficiency of C1QBP was confirmed using real-time qPCR and western blot in MDA-MB-468-shC1QBP cells. (D) Migration and invasion analysis indicates differential cell motilities in MDA-MB-468 cells. (E) Upper: cell viabilities were determined in MDA-MB-468-control and shC1QBP cells incubated with PTX for 24 h by MTS. Lower: comparison of the IC50 values and resistance indices of control and shC1QBP groups. Three independent experiments were used to represent the mean ± standard deviation values. *P < 0.05, **P < 0.01, ***P < 0.0001, and ****P < 0.0001.