Fig. 2. Added value of the genotype-first approach to the identification of high-risk individuals.
The number of high-risk individuals who have been to a medical geneticist is limited. Majority of the families do not meet the NCCN criteria to be classified as having high risk for HBOC. Only limited number of female carriers had breast cancer diagnosis at an age group covered by the national breast cancer screening program. 1Self-reported family history of hereditary breast and ovarian cancer-related cancers indicative of high risk.