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. 2021 Mar 8;5:18. doi: 10.1038/s41698-021-00154-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — In colorectal tumor microenvironment, IL-1β derived from infiltrated neutrophils, macrophages, and dendritic cells enhances CRC progression through production of IL-6 and IL-17A from lamina propria, macrophages, and dendritic cells. On the other hand, NLRP3 in bone marrow cells, NLRC4 and NLRC6 in hematopoietic cells, and NLRC4 in colon epithelial cells play tumor suppressive roles in CAC development.