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. 2021 Mar 8;11:5418. doi: 10.1038/s41598-021-84123-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map showing overview of key results. All quantitative results were assigned to one of the following categories zero, low, medium and high and color-coded accordingly. The investigated scaffolds of the four experimental groups 2D-single cells (2D-SCs), 3D-microtissues (3D-MTs) and corresponding secretomes were either analyzed as an entire scaffold (Total) or one of the three regions interface (I), middle (M) and surface (S).