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. 2021 Feb 23;10:620550. doi: 10.3389/fonc.2020.620550

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Copyright © 2021 Nie, Zhang, He, Wang, Wan, Wang and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of XLOC_012370 promotes proliferation, migration, and invasion in PANC-1 and BxPC-3 cells. (A) Efficiencies of XLOC_012370 knockdown in PANC-1 and BxPC-3 cells were detected by qRT-PCR assays. n=5, *P < 0.05. (B) The cell viability of sh- XLOC_012370-transfected PANC-1 and BxPC-3 cells were detected by CCK-8 assays. n=6, *P<0.05. (C) Effect of XLOC_012370 knockdown on colony formation was counted in PANC-1 and BxPC-3 cells. n=4, *P < 0.05. (D) Representative images and histogram analysis of EdU assays after XLOC_012370 knockdown in PANC-1 and BxPC-3 cells. n=3, *P <0.05. (E) Wound healing assays after XLOC_012370 knockdown in PANC-1 and BxPC-3 cells. n=3, *P < 0.05. (F) Representative images and histogram analysis of transwell assays after XLOC_012370 knockdown in PANC-1 and BxPC-3 cells. n=4, *P < 0.05. (G) The protein level of IκBα, P65, and p-P65 were detected in PANC-1 cells.