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. 2021 Feb 23;12:616650. doi: 10.3389/fimmu.2021.616650

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Copyright © 2021 Frasca, Diaz, Romero and Blomberg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DN B cells are characterized by higher expression of IA markers associated with autoimmunity. (A) Cells were stained to evaluate the expression of several markers of IA on DN B cells from individuals with obesity and from lean controls. Results show mean fluorescence intensity (MFI)± SE for each marker in DN B cells from lean (black line) and obese (red line) individuals (18 individuals/group). (B) PCA analysis with the axes showing the percentage of variation explained by PC1 and PC2. Each symbol indicates an individual. White symbols: lean individuals. Red symbols: obese individuals.