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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: J Allergy Clin Immunol. 2020 Oct 13;147(3):1087–1092.e3. doi: 10.1016/j.jaci.2020.10.005

Fig. 4. Adenosine receptor signaling promotes suppressive activity in alveolar macrophages.

Fig. 4.

A, Foxp3− OT-II T cells were cultured with OVA and naïve or CFSE+ macrophages sorted from BAL and lung, in the presence or absence of ATL. % Foxp3+ T cells. B, mRNA in alveolar macrophages cultured with ATL in vitro. C-E, Mice were given ATL and sensitized and challenged as in Fig. 1 with HDM. BAL total cells, eosinophils, Th2 cytokines, lung H&E, and inflammation score. n = 6–9 mice/group. F, Alveolar macrophages were depleted with clodronate liposomes before treatment with ATL and sensitization with HDM. BAL eosinophils and Th2 cytokines. n = 5 mice/group. All data representative of 2–3 experiments.