Table 2.
Summary of guardian-perceived responses to memantine utilizing the GRSC and healthcare provider-perceived responses to memantine utilizing the CGI-I Scale.
| Patient | Question 1 With respect to your child’s motor function, how would you rate after starting memantine? |
Question 2 With respect to your child’s behavior, how would you rate it after starting memantine? |
Question 3 With respect to your child’s learning abilities how would you rate it after memantine? |
|---|---|---|---|
| Global Rating Scale of Change (GRSC): The scale ranges from −5 to +5 with a rating of −5 indicating severe worsening, a rating of 0 indicating no change, and a rating of +5 indicating complete recovery. | |||
| 1 | 3 | 2 | 5 |
| 2 | 5 | 0 | 5 |
| 3 | 3 | 0 | 0 |
| 4* | - | - | - |
| 5 | 4 | 3 | 3 |
| Clinical Global Impression of Improvement (CGI-I): The scale ranges from 1 to 7 with a rating of 1 indicating a very substantial improvement, a score of 4 indicating no change, and a score of 7 indicating severe symptom exacerbation. | |||
| 1 | 3 | 3 | 2 |
| 2 | 2 | 2 | 2 |
| 3 | 2 | 4 | 2 |
| 4 | 5 | 4 | 2 |
| 5 | 2 | 2 | 2 |
*
The guardians of patient 4 were unable to be contacted to complete the GRSC.