Table 2.
Variable | From multiple IAa to type 1 diabetes (n=133) | Type 1 diabetes (n=172) | |||||
---|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | ||
Overweight (%) | |||||||
2 years | 1.83 | 0.84, 3.98 | 0.13 | 1.26 | 0.71, 2.21 | 0.43 | |
3 years | 3.61 | 1.73, 7.54 | <0.001 | 1.07 | 0.62, 1.83 | 0.82 | |
4 years | 1.65 | 0.85, 3.21 | 0.14 | 1.50 | 0.89, 2.52 | 0.13 | |
5 years | 1.96 | 1.03, 3.72 | 0.04 | 1.75 | 1.03, 2.96 | 0.04 | |
6 years | 3.01 | 1.37, 6.64 | 0.006 | 1.86 | 1.05, 3.31 | 0.03 | |
7 years | 2.84 | 1.25, 6.44 | 0.01 | 1.49 | 0.82, 2.72 | 0.19 | |
8 years | 2.41 | 1.09, 5.31 | 0.03 | 1.42 | 0.77, 2.62 | 0.26 | |
9 years | 2.36 | 0.68, 8.25 | 0.18 | 1.35 | 0.66, 2.77 | 0.41 | |
10 years | 2.30 | 0.41, 13.02 | 0.34 | 1.31 | 0.53, 3.26 | 0.56 | |
Obesity (%) | |||||||
2 years | 6.76 | 1.68, 27.28 | 0.007 | 1.59 | 0.50, 5.08 | 0.44 | |
3 years | 18.88 | 4.27, 83.45 | <0.001 | 1.73 | 0.63, 4.77 | 0.29 | |
4 years | 1.83 | 0.56, 5.99 | 0.32 | 1.44 | 0.52, 4.00 | 0.48 | |
5 years | 2.79 | 0.77, 10.05 | 0.12 | 1.83 | 0.78, 4.31 | 0.17 | |
6 years | 3.38 | 1.07, 10.68 | 0.04 | 2.40 | 1.12, 5.14 | 0.02 | |
7 years | 1.61 | 0.46, 5.61 | 0.46 | 1.60 | 0.67, 3.83 | 0.29 | |
8 years | 1.96 | 0.71, 5.45 | 0.20 | 2.07 | 0.94, 4.55 | 0.07 | |
9 years | 1.54 | 0.31, 7.57 | 0.59 | 1.98 | 0.74, 5.33 | 0.18 | |
10 years | 70.85 | 1.11, 4529.89 | 0.04 | 2.15 | 0.68, 6.83 | 0.19 | |
Overweight up to 10 years | 2.17 | 1.12, 4.19 | 0.02 | 2.39 | 1.46, 3.92 | <0.001 | |
Obesity up to 10 years | 0.98 | 0.21, 4.61 | 0.98 | 2.08 | 0.93, 4.64 | 0.07 | |
Overweight (joint modelling) | 2.16 | 1.40, 3.21 | 0.004 | ||||
Obesity (joint modelling) |
HRs adjusted for birthweight z score and birth length z score, sex, HLA risk, maternal type 1 diabetes status, mode of delivery and breastfeeding duration, and stratified by region of residence. Presented p values are nominal (uncorrected) p values, and were considered significant if <0.005. Shaded analyses: model failed to converge
Antibodies include IAA, IA-2A, GADA and ZnT8A; the number of children with multiple IA=190