Table II.
Upstream regulators identified by Ingenuity Pathway Analysis with electron transport chain proteins as potential downstream targets. Upstream regulators that are likely regulators of MT-ND1, a subunit of complex I that is encoded by mitochondrial DNA are designated by *. Significance was determined using a false discovery rate p<0.05.
| Protein Name | Gene ID | P value |
|---|---|---|
| * Amyloid Beta Precursor Protein | APP | 1.07E-03 |
| Calcium Binding Protein 39 Like | CAB39L | 6.26E-05 |
| Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit | CLPP | 2.47E-02 |
| Cytochrome P450 Family 1 Subfamily A Member 1 | CYP1A1 | 4.24E-02 |
| * Dystrophin | DMD | 2.98E-05 |
| Epidermal Growth Factor Receptor | EGFR | 8.63E-04 |
| Erb-B2 Receptor Tyrosine Kinase 2 | ERBB2 | 9.17E-03 |
| Estrogen Receptor 1 | ESR1 | 4.26E-03 |
| Forkhead Box O1 | FOXO1 | 8.93E-03 |
| Hemoglobin Subunit Alpha 1/ Hemoglobin Subunit Alpha 2 | HBA1/HBA2 | 7.09E-03 |
| Hepatocyte Nuclear Factor 4 Alpha | HNF4A | 2.03E-03 |
| Huntingtin | HTT | 2.16E-06 |
| Insulin Like Growth Factor 1 Receptor | IGF1R | 3.94E-06 |
| Insulin Receptor | INSR | 7.87E-03 |
| *Insulin | insulin | 8.59E-04 |
| Lysine Demethylase 5A | KDM5A | 1.69E-06 |
| Microtubule Associated Protein Tau | MAPT | 3.35E-04 |
| MYC Proto-Oncogene, BHLH Transcription Factor | MYC | 1.21E-05 |
| Nuclear Receptor Subfamily 4 Group A Member 1 | NR4A1 | 9.98E-04 |
| Nuclear Receptor Subfamily 4 Group A Member 3 | NR4A3 | 2.38E-02 |
| O-GlcNAcase | OGA | 1.07E-03 |
| Pyruvate Kinase M1/2 | PKM | 8.93E-03 |
| Phospholipase A2 Receptor 1 | PLA2R1 | 8.95E-04 |
| PPARG Coactivator 1 Alpha | PPARGC1A | 2.92E-04 |
| Presenilin 1 | PSEN1 | 5.07E-04 |
| RB Transcriptional Corepressor 1 | RB1 | 3.66E-03 |
| RPTOR Independent Companion Of MTOR Complex 2 | RICTOR | 3.34E-05 |
| Ryanodine Receptor 1 | RYR1 | 1.35E-02 |
| * SET And MYND Domain Containing 1 | SMYD1 | 1.22E-02 |
| Serine/Threonine Kinase 11 | STK11 | 8.23E-04 |
| Transforming Growth Factor Beta 1 | TGFB1 | 3.12E-07 |
| * TLE Family Member 3, Transcriptional Corepressor | TLE3 | 3.91E-07 |
| Tumor Protein P53 | TP53 | 2.43E-09 |
| Uncoupling Protein 1 | UCP1 | 2.13E-02 |
| Zinc Finger Protein 106 | ZNF106 | 2.47E-02 |