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. 2021 Mar 8;11:5442. doi: 10.1038/s41598-021-84828-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LC/MS–MS analysis in decellularized subcutaneous adipose tissue from WT and KO mice. (A) Venn diagram summary showing protein variability between WT and KO (only included proteins that were expressed in all replicates). Comparison between (B) biological processes, and (C) molecular functions signaling pathways showed that WT and KO ECM had differences in the “binding” and “response to stimulus” signaling pathways. Proteins were quantified using the exponentially modified protein abundance index (emPAI), which relates the number of unique peptides observed for a specific protein to the number of observable peptides in the sample. n = 3 biological samples with 3 technical replicates. The significance threshold was set at p < 0.05, with a False Discovery Rate of 5% using ANOVA.