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. 2021 Mar 8;11:5442. doi: 10.1038/s41598-021-84828-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Matrix protein and integrin differences between subcutaneous adipose tissue from WT and KO mice. (A) In addition to the expected absence of laminin α4 in the adipose ECM, there was a significant decrease in laminin gamma 1 (LAMC1). (B) When evaluating proteins involved in cell binding and integrin signaling, integrins α7 (ITA7) and β1 (ITB1) were dramatically reduced in the subcutaneous adipose from KO mice. (C) Both collagen 1A1 (CO1A1) and collagen 3A1 (CO3A1) were significantly lower in subcutaneous adipose tissue from KO mice. n = 3 biological samples with 3 technical replicates. Data are presented as mean ± standard error of the mean with *p < 0.05, **p < 0.01, ****p < 0.0001 as significant from one-way ANOVA.