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. 2021 Mar 8;11:5433. doi: 10.1038/s41598-021-84782-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Binding of famotidine to PL^pro and 3CL^pro analyzed by SPR. Soluble biotinylated PL^pro (a, b) and 3CL^pro (c, d) were immobilized on a neutravidin-coated sensor chip and a range of compound concentrations were injected with solvent (DMSO) corrections. Both, (a) compound 6, the known PL^pro inhibitor and (c) ML188, the 3CL^pro inhibitor displayed dose-dependent binding to PL^pro and 3CL^pro, respectively. Whereas, (b, d) no binding of famotidine was detected to either protein. The dissociation constant (K_d) values for the control compounds are shown in Table S1 (Supplementry Information).