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. 2021 Mar 8;11:5405. doi: 10.1038/s41598-021-84860-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Disease pairs with statistically significant differences in their associations with risk factors at the 0.05 level after an FDR multiple-testing adjustment. With all associations (left), and without BMI (right). Red indicates an association with higher risk for women than men, white a lower risk, and orange neutral. Without BMI as a risk factor, only two diseases continue to have statistically significant differences. The figures were produced with R³⁴ and the “gplots”⁴¹ package.