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. 2021 Mar 8;11:5446. doi: 10.1038/s41598-021-83362-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Kaplan–Meier survival curve according to CAR. Patients were stratified according to the cutoff value of CAR (0.032). The OS rate was 79.1% for patients with a low CAR (< 0.032) and 35% for a high CAR (≥ 0.032) (P < 0.001). (B)–(E) Kaplan–Meier survival curves according to NLR, SIRI, SII, and LMR. Significant differences in OS were noted when the patient cohort was subdivided into two groups according to the cutoff value of each inflammatory marker (NLR < 3.59, 70.0% vs. NLR ≥ 3.59, 50.4%, P < 0.001; SIRI < 1.19, 71.7% vs. SIRI ≥ 1.19, 47.7%, P = 0.001; SII < 823.1, 70.3% vs. SII ≥ 823.1, 50.1%, P < 0.001; and LMR ≥ 5.0, 75.2% vs. LMR < 5.0, 56.1%, P < 0.001). A less favorable prognosis was associated with a higher NLR, SIRI, and SII values and a lower LMR value.