Table 1.
Clinical characteristics of the patients included in the study dichotomized according to the cutoff value of CAR.
| Variable | Total No. of patients |
CAR < 0.032 No. of patients (%) n = 134 |
CAR ≧ 0.032 No. of patients (%) n = 71 |
P value | |
|---|---|---|---|---|---|
| Age (years) | 0.007** | ||||
| Median (range) | 71.3 (31.1–93.0) | 71.0 (31.1–93.0) | 73.2 (49.3–92.6) | ||
| BMI (kg/m2) | 0.211 | ||||
| Median (range) | 22.49 (13.51–34.21) | 22.65 (13.51–32.54) | 22.14 (15.84–34.21) | ||
| Gender | Male | 123 | 80 (65.0) | 43 (35.0) | 0.905 |
| Female | 82 | 54 (65.9) | 28 (34.1) | ||
| Tabaco consumption | Present | 27 | 16 (59.3) | 11 (40.7) | 0.754 |
| Pre | 31 | 20 (64.5) | 11 (35.5) | ||
| Never | 147 | 98 (66.7) | 49 (33.3) | ||
| Alcohol consumption | Present | 65 | 44 (67.7) | 21 (32.3) | 0.633 |
| None | 140 | 90 (64.3) | 50 (35.7) | ||
| Primary site | Tongue | 76 | 60 (78.9) | 16 (21.1) | 0.003** |
| Lower gingiva | 65 | 40 (61.5) | 25 (38.5) | ||
| Buccal mucosa | 22 | 14 (63.6) | 8 (36.4) | ||
| Upper gingiva | 19 | 9 (47.4) | 10 (52.6) | ||
| Floor of the mouth | 13 | 7 (53.8) | 6 (46.2) | ||
| Others | 10 | 4 (40.0) | 6 (60.0) | ||
| T classification | T1 | 40 | 37 (92.5) | 3 (7.5) | < 0.001** |
| T2 | 62 | 46 (74.2) | 16 (25.8) | ||
| T3 | 35 | 24 (68.6) | 11 (31.4) | ||
| T4a | 56 | 24 (42.9) | 32 (57.1) | ||
| T4b | 12 | 3 (25.0) | 9 (75.0) | ||
| N classification | N0 | 132 | 94 (71.2) | 38 (28.8) | 0.003** |
| N1 | 25 | 18 (72.0) | 7 (28.0) | ||
| N2a | 1 | 1 (100) | 0 (0) | ||
| N2b | 35 | 19 (54.3) | 16 (45.7) | ||
| N2c | 10 | 2 (20.0) | 8 (80.0) | ||
| N3b | 2 | 0 (0) | 2 (100) | ||
| M classification | M0 | 204 | 134 (65.7) | 70 (34.3) | 0.346 |
| M1 | 1 | 0 (0) | 1 (100) | ||
| Stage | I | 38 | 35 (92.1) | 3 (7.9) | < 0.001** |
| II | 52 | 39 (75.0) | 13 (25.0) | ||
| III | 28 | 20 (71.4) | 8 (28.6) | ||
| IVA | 73 | 37 (50.7) | 36 (49.3) | ||
| IVB | 13 | 3 (23.1) | 10 (76.9) | ||
| IVC | 1 | 0 (0) | 1 (100) | ||
| Histological grade | Well | 105 | 71 (67.6) | 34 (32.4) | 0.225 |
| Moderate | 80 | 53 (66.3) | 27 (33.7) | ||
| Poor | 11 | 4 (36.4) | 7 (63.6) | ||
| Others | 9 | 6 (66.7) | 3 (33.3) | ||
| NLR | ≥ 3.59 | 51 | 21 (41.2) | 30 (58.8) | < 0.001** |
| < 3.59 | 154 | 113 (73.4) | 41 (26.6) | ||
| SIRI | ≥ 1.19 | 59 | 24 (40.7) | 35 (59.3) | < 0.001** |
| < 1.19 | 146 | 110 (75.3) | 36 (24.7) | ||
| SII | ≥ 823.1 | 51 | 20 (39.2) | 31 (60.8) | < 0.001** |
| < 823.1 | 154 | 114 (74.0) | 40 (26.0) | ||
| LMR | ≥ 5.0 | 95 | 76 (80.0) | 19 (20.0) | < 0.001** |
| < 5.0 | 110 | 58 (52.7) | 52 (47.3) | ||
| Management | Surgery | 116 | 89 (76.7) | 27 (23.3) | < 0.001** |
| Surgery + radiotherapy or chemoradiotherapy | 51 | 36 (70.6) | 15 (29.4) | ||
| Radiotherapy | 38 | 9 (23.7) | 29 (76.3) | ||
| Local recurrence | Present | 39 | 15 (38.5) | 24 (61.5) | < 0.001** |
| None | 166 | 119 (71.7) | 47 (28.3) | ||
| Neck recurrence | Present | 15 | 9 (60.0) | 6 (40.0) | 0.650 |
| None | 190 | 125 (65.8) | 65 (34.2) | ||
| Distant metastasis | Present | 20 | 13 (65.0) | 7 (35.0) | 0.971 |
| None | 185 | 121 (65.4) | 64 (34.6) |
*P < 0.05 Statistically significant difference.
**P < 0.01 Statistically significant difference.
NLR, neutrophil/lymphocyte ratio; SIRI, systemic Inflammation Response Index; LMR, lymphocyte/ monocyte ratio; SII, systemic immune-inflammation index; CAR, C-reactive protein/albumin ratio.