Table 4.
Univariate and multivariate cox regression analyses for OS in the primary cohort.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P values† | HR (95% CI) | P values† | |
| Gender | ||||
| Male vs. Female | 0.839 (0.502–1.402) | 0.502 | – | – |
| Age | ||||
| < 71.3vs. ≥ 71.3 | 2.077 (1.224–3.527) | 0.007** | 2.155 (1.262–3.682) | 0.005** |
| T classification | ||||
| T1, 2 vs. T3, 4 | 3.160 (1.779–5.613) | < 0.001** | ||
| N classification | ||||
| N0, 1 vs. N2, 3 | 2.285 (1.347–3.878) | 0.002** | ||
| Stage | ||||
| I, II vs. III, IV | 3.617 (1.918–6.824) | < 0.001** | 3.031 (1.576–5.827) | 0.001** |
| NLR | ||||
| < 3.59 vs. ≥ 3.59 | 2.681 (1.593–4.512) | < 0.001** | – | – |
| SIRI | ||||
| < 1.19 vs. ≥ 1.19 | 2.423 (1.447–4.059) | 0.001** | – | – |
| SII | ||||
| < 823.1vs. ≥ 823.1 | 2.578 (1.532–4.340) | < 0.001** | – | – |
| LMR | ||||
| < 5.0 vs. ≥ 5.0 | 0.380 (0.218–0.663) | 0.001** | – | – |
| CAR | ||||
| < 0.032 vs. ≥ 0.032 | 3.839 (2.275–6.476) | < 0.001** | 2.859 (1.667–4.904) | < 0.001** |
†By Cox proportional hazards regression.
*P < 0.05 Statistically significant difference, **P < 0.01 Statistically significant difference.
NLR, neutrophil lymphocyte ratio; SIRI, systemic inflammation response index; LMR, lymphocyte monocyte ratio; SII, systemic immune-inflammation index; CAR, C-reactive protein/albumin ratio.