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Homotaurine treatment initiated just before the second attack prevents EAE relapse. EAE was induced in SJL mice using PLP139-151 (as in26). Twenty-two days post-immunization, some mice were given homotaurine (0.25 mg/ml) continuously through their drinking water. The black bar indicates the period of homotaurine treatment. *p < 0.05, ***p < 0.001 vs. plain water control group by Student’s t-test. N = 11–12 mice/group.
