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. 2021 Mar 8;11:5402. doi: 10.1038/s41598-021-84751-3

Figure 3.

Figure 3

Homotaurine treatment limits the spreading of T cell autoreactivity within the CNS. SJL mice were immunized with PLP139-151 and 15 days later, near the first peak of clinical symptoms, mice were placed on plain water or containing homotaurine (0.25 mg/ml) for the rest of the experiment. Thirty days later, we analyzed the frequency of T cells which secreted IFNγ or IL-17A in response to PLP139-151 and PLP178-191 in the spleens (panel A) or CNS (panel B) of individual mice by ELISPOT. N = 6 mice/group. ***p < 0.001 by Student’s t-test.