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. 2021 Feb 23;12:627541. doi: 10.3389/fimmu.2021.627541

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Copyright © 2021 Abbade, Barraviera, Silvares, Lima, Haddad, Gatti, Medolago, Rigotto Carneiro, dos Santos, Ferreira and Barraviera

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heterologous Fibrin Sealant Package with the three bottles. Diluent vial (white stripe) containing 0.6 mL of calcium chloride; Fraction 1 vial (red stripe) containing 0.4 mL of serine protease extracted from the venom of Crotalus durissus terrificus; Fraction 2 vial (black stripe) containing 1 mL of cryoprecipitate rich in fibrinogen and coagulation factors extracted from buffaloes. (B) Application investigational product on the ulcerated bed. Y-connector using two syringes (in detail) with 1 mL of components each one. (C) Detail of fibrin adhered to the ulcer. (D) After covering the ulcer bed with gauze soaked in essential fatty acids, the Unna boot was applied.