Figure 1.

No-fiber diet feeding modifies gut microbiota. WT mice were fed either a control (CON) or no fiber (NF) diet for 14 days. At days 0, 3, 7, 10, or 14 of diet, fecal samples were collected and 16S rRNA sequencing performed. (A) The abundance (%) of the top 20 bacteria at the genera level. (B) Principle coefficient analysis (PCA) of CON and NF groups at the OTU level, and Adonis UniFrac was performed. At day 14, the diversity of the gut microbial composition was quantified by analysis of richness (C) and Pearson’s correlation at the genera level were performed (D). Dots represent individual mice, N ≥ 4 per time point per diet group.