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. 2021 Feb 23;12:639254. doi: 10.3389/fgene.2021.639254

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Copyright © 2021 Wang, Yin, Zhang and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The top enriched gene sets in up- and down-regulated DEGs in the high-risk group. (A) Gene sets enriched in DEGs up-regulated in the high-risk group. G2M checkpoints and E2F target-related genes were significantly enriched. (B) Gene sets enriched in DEGs down-regulated in the high-risk group. Genes related to interleukin, STAT, KRAS, and p53 were enriched, while cell mitosis-related genes were significantly deprived.