Table 1.
Clinical and demographic characteristics of the discovery cohort.
| Discovery set | All (n = 540) | Early fibrosis (S0–2) (n = 391) | Advanced fibrosis (S3–4) (n = 149) | p-value |
|---|---|---|---|---|
| Age (year) | 46.76 ± 13.42 | 44.39 ± 13.44 | 52.99 ± 11.22 | <0.001 |
| ALB (g/L) | 4.44 ± 0.41 | 4.46 ± 0.43 | 4.37 ± 0.37 | 0.087 |
| ALT (IU/L) | 76.50 ± 49.94 | 76.25 ± 50.83 | 77.14 ± 47.69 | 0.664 |
| AST (IU/L) | 47.11 ± 26.40 | 44.17 ± 25.98 | 54.81 ± 26.00 | <0.001 |
| BMI (kg/m2) | 30.38 ± 5.18 | 30.23 ± 5.28 | 30.79 ± 4.87 | 0.200 |
| FBG (mmol/L) | 6.36 ± 2.01 | 6.10 ± 1.80 | 7.03 ± 2.38 | <0.001 |
| GGT (IU/L) | 67.77 ± 60.97 | 64.98 ± 63.51 | 75.08 ± 53.25 | <0.001 |
| HbA1c (%) | 6.61 ± 1.43 | 6.52 ± 1.44 | 6.86 ± 1.39 | 0.001 |
| HDL (mmol/L) | 1.11 ± 0.28 | 1.10 ± 0.26 | 1.14 ± 0.33 | 0.115 |
| LDL (mmol/L) | 2.95 ± 1.16 | 3.01 ± 1.20 | 2.76 ± 1.01 | 0.134 |
| PLT (109/L) | 226.70 ± 61.46 | 235.70 ± 61.20 | 203.07 ± 55.79 | <0.001 |
| TBIL (μmol/L) | 12.45 ± 7.08 | 12.27 ± 7.30 | 12.93 ± 6.45 | 0.095 |
| TC (mmol/L) | 5.01 ± 1.23 | 5.06 ± 1.29 | 4.88 ± 1.06 | 0.423 |
| TG (mmol/L) | 2.02 ± 1.43 | 2.14 ± 1.58 | 1.72 ± 0.87 | 0.001 |
| AST/ALT | 0.73 ± 0.38 | 0.70 ± 0.41 | 0.80 ± 0.28 | <0.001 |
| AST/PLT | 0.57 ± 0.39 | 0.50 ± 0.31 | 0.75 ± 0.49 | <0.001 |
| DM/IFG (no/yes) | 233:307 | 190:201 | 43:106 | <0.001 |
| Sex (M/F) | 282:258 | 221:170 | 61:88 | 0.002 |
Values are expressed as mean ± SD. P-values determined by comparing the characteristics of individuals with early (fibrosis stage 0–2) and advanced fibrosis (fibrosis stage 3–4) were evaluated using an independent-samples t-test or Wilcoxon–Mann–Whitney test. Chi-square test or Fisher's exact test, when appropriate, was used to compare categorical variables.
ALB, albumin; ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; FBG, fasting blood glucose; GGT, gamma-glutamyl transferase; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PLT, platelet; TBIL, total bilirubin; TC, total cholesterol; TG, triglyceride; DM/IFG, presence of diabetes or impaired fasting glycemia.