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. 2021 Feb 23;10:616185. doi: 10.3389/fonc.2020.616185

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Copyright © 2021 Qin, Du, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increasing FBXW7 protein level suppress PCa cell viability by inhibiting key human cancer proteins. (A–C) The relative cell number of two cell lines after FBXW7 overexpression by plasmid vectors. (D) The result of immunoblotting performed by indicated antibodies. (E, F) The change of relative expression level of each protein compared by control group. Values are expressed as the mean ± SEM.*P < 0.05, ***P<0.001, n = 3, relative to the vector group. Protein levels were normalized by GADPH.