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. 2021 Feb 23;12:636027. doi: 10.3389/fphys.2021.636027

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Copyright © 2021 Olsen, Fischer, Evans, Gliemann and Hellsten.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the influence of acute exercise and habitually active lifestyle on hemostasis. (A) Resting hemostasis in a healthy individual. (B) Exercise accustomed individual: exercise-induced pro-thrombotic factors are counterbalanced by the release of anti-thrombotic and anti-aggregatory agents, e.g., prostacyclin and NO. (C) Sedentary individual: the exercise-induced increase in thrombogenic factors is not sufficiently counterbalanced by anti-thrombotic protection leading to a thrombogenic response. Illustration created with BioRender.