Figure 2.

Whole-genome sequencing of donor EP, iPSC-RPE and iPSC MCB. (A) The flow chart describes donor EP, iPSC MCB, and iPSC-RPE whole-genome DNA sequence analysis pipelines for germline and somatic variant calling, filtration, and annotation. (B) Genome-wide functional annotation of germline and somatic SNVs based on their relative location in the genome. (C) The bar chart shows somatic variants of iPSC-RPE and iPSC MCB, iPSC-RPE: somatic SNVs and InDels for iPSC-RPE vs. donor EP; iPSC MCB: somatic SNVs and InDels for iPSC MCB vs. donor EP; SNV, single nucleotide variant; InDel, small insertion and deletion; Exonic, somatic nonsynonymous variant; ncRNA, noncoding RNA.