Table 1. Patient Characteristics of T790M mutant group.
| Patient characteristics | Total | Metastases | Brain metastases | Bone metastases | Liver metastases | Intrapulmonary metastases | Other sites metastases | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes, n (%) | No, n (%) | P | Yes, n (%) | No, n (%) | P | Yes, n (%) | No, n (%) | P | Yes, n (%) | No, n (%) | P | Yes, n (%) | No, n (%) | P | Yes, n (%) | No, n (%) | P | |||||||
| Total | 316 | 277 (87.7) | 39 (12.3) | 119 (37.7) | 197 (62.3) | 121 (38.3) | 121 (38.3) | 36 (11.4) | 280 (88.6) | 224 (70.9) | 92 (29.1) | 48 (15.2) | 268 (84.8) | |||||||||||
| Age | 0.002 | 0.004 | 0.022 | 0.011 | 0.435 | 0.013 | ||||||||||||||||||
| <70 | 246 | 223 (90.7) | 23 (9.3) | 103 (41.9) | 143 (58.1) | 86 (35.0) | 86 (35.0) | 34 (13.8) | 212 (86.2) | 177 (72.0) | 69 (28.0) | 44 (17.9) | 202 (82.1) | |||||||||||
| ≥70 | 70 | 54 (77.1) | 16 (22.9) | 16 (22.9) | 54 (77.1) | 35 (50.0) | 35 (50.0) | 2 (2.9) | 68 (97.1) | 47 (67.1) | 23 (32.9) | 4 (5.7) | 66 (94.3) | |||||||||||
| Sex | 0.128 | 0.583 | 0.17 | 0.077 | 0.141 | 0.726 | ||||||||||||||||||
| Male | 131 | 116 (88.5) | 15 (11.5) | 47 (35.9) | 84 (64.1) | 56 (42.7) | 56 (42.7) | 10 (7.6) | 121 (92.4) | 87 (66.4) | 44 (33.6) | 21 (16.0) | 110 (84.0) | |||||||||||
| Female | 185 | 161 (87.0) | 24 (13.0) | 72 (38.9) | 113 (61.1) | 65 (35.1) | 65 (35.1) | 26 (14.1) | 159 (85.9) | 137 (74.1) | 48 (25.9) | 27 (14.6) | 158 (85.4) | |||||||||||
| Smoking | 0.000 | 0.457 | 0.002 | 0.251 | 0.082 | 0.136 | ||||||||||||||||||
| Smoked | 57 | 42 (73.7) | 15 (26.3) | 19 (33.3) | 38 (66.7) | 32 (56.1) | 32 (56.1) | 4 (7.0) | 53 (93.0) | 35 (61.4) | 22 (38.6) | 5 (8.8) | 52 (91.2) | |||||||||||
| Non-smoked | 259 | 235 (90.7) | 24 (9.3) | 100 (38.6) | 159 (61.4) | 89 (34.4) | 89 (34.4) | 32 (12.4) | 227 (87.6) | 189 (73.0) | 70 (27.0) | 43 (16.6) | 216 (83.4) | |||||||||||
| Pathology | 0.611 | 0.032 | 0.696 | 0.327 | 0.315 | 0.348 | ||||||||||||||||||
| Squamous | 7 | 6 (85.7) | 1 (14.3) | 7 (100.0) | 3 (42.9) | 3 (42.9) | 7 (100.0) | 4 (57.1) | 3 (42.9) | 2 (28.6) | 5 (71.4) | |||||||||||||
| Non-squamous | 309 | 271 (91.2) | 26 (8.8) | 119 (40.1) | 178 (59.9) | 106 (35.7) | 106 (35.7) | 36 (12.1) | 261 (87.9) | 220 (74.1) | 77 (25.9) | 46 (15.5) | 251 (84.5) | |||||||||||
| T | 0.988 | 0.344 | 0.305 | 0.315 | 0.294 | 0.847 | ||||||||||||||||||
| 1 | 20 | 19 (95.0) | 1 (5.0) | 6 (30.0) | 14 (70.0) | 9 (45.0) | 9 (45.0) | 1 (5.0) | 19 (95.0) | 13 (65.0) | 7 (35.0) | 3 (15.0) | 17 (85.0) | |||||||||||
| 2−4 | 270 | 249 (92.2) | 21 (7.8) | 110 (40.7) | 160 (59.3) | 91 (33.7) | 91 (33.7) | 34 (12.6) | 236 (87.4) | 204 (75.6) | 66 (24.4) | 45 (16.7) | 225 (83.3) | |||||||||||
| N | 0.007 | 0.009 | 0.000 | 0.764 | 0.243 | 0.14 | ||||||||||||||||||
| 0 | 29 | 23 (79.3) | 6 (20.7) | 5 (17.2) | 24 (82.8) | 19 (65.5) | 19 (65.5) | 3 (10.3) | 26 (89.7) | 19 (65.5) | 10 (34.5) | 2 (6.9) | 27 (93.1) | |||||||||||
| 1−3 | 261 | 244 (93.5) | 17 (6.5) | 110 (42.1) | 151 (57.9) | 82 (31.4) | 82 (31.4) | 32 (12.3) | 229 (87.7) | 197 (75.5) | 64 (24.5) | 46 (17.6) | 215 (82.4) | |||||||||||
| Stage | 0.000 | 0.158 | 0.018 | 0.52 | 0.003 | 0.447 | ||||||||||||||||||
| I−II | 3 | 3 (100.0) | 3 (100.0) | 3 (100.0) | 3 (100.0) | 3 (100.0) | 3 (100.0) | 3 (100.0) | ||||||||||||||||
| III−V | 297 | 277 (93.3) | 20 (6.7) | 119 (40.1) | 178 (59.9) | 102 (34.3) | 102 (34.3) | 36 (12.1) | 261 (87.9) | 224 (75.4) | 73 (24.6) | 48 (16.2) | 249 (83.8) | |||||||||||
| EGFR 19 DEL | 0.036 | 0.927 | 0.565 | 0.108 | 0.489 | 0.027 | ||||||||||||||||||
| Negative | 145 | 121 (83.4) | 24 (16.6) | 55 (37.9) | 90 (62.1) | 58 (40.0) | 58 (40.0) | 12 (8.3) | 133 (91.7) | 100 (69.0) | 45 (31.0) | 15 (10.3) | 130 (89.7) | |||||||||||
| Positive | 171 | 156 (91.2) | 15 (8.8) | 64 (37.4) | 107 (62.6) | 63 (36.8) | 63 (36.8) | 24 (14.0) | 147 (86.0) | 124 (72.5) | 47 (27.5) | 33 (19.3) | 138 (80.7) | |||||||||||
| EGFR L858R | 0.224 | 0.273 | 0.215 | 0.471 | 0.928 | 0.055 | ||||||||||||||||||
| Negative | 198 | 177 (89.4) | 21 (10.6) | 70 (35.4) | 128 (64.6) | 117 (59.1) | 81 (40.9) | 25 (12.6) | 173 (87.4) | 140 (70.7) | 58 (29.3) | 36 (18.2) | 162 (81.8) | |||||||||||
| Positive | 118 | 100 (84.7) | 18 (15.3) | 49 (41.5) | 69 (58.5) | 78 (66.1) | 40 (33.9) | 11 (9.3) | 107 (90.7) | 84 (71.2) | 34 (28.8) | 12 (10.2) | 106 (89.8) | |||||||||||
| EGFR T790M | ||||||||||||||||||||||||
| Negative | 0 | |||||||||||||||||||||||
| Positive | 316 | 277 (87.7) | 39 (12.3) | 119 (37.7) | 197 (62.3) | 121 (38.3) | 121 (38.3) | 36 (11.4) | 280 (88.6) | 224 (70.9) | 92 (29.1) | 48 (15.2) | 268 (84.8) | |||||||||||
EGFR, epidermal growth factor receptor; T790M, a mutation that substitutes methionine for threonine at amino acid position 790; 19 DEL, exon 19 deletion; L858R, substitutions of leucine for arginine in exon 21.