Table 2. Y-chromosome loss and clinical characteristics in clear cell (ccRCC) and papillary renal cell cancer (pRCC-including subgroup type 1 and type 2). The percentage of tumors harboring a Y-chromosome is given for each histological category (ISUP International Society of Urological Pathology).

Parameter	ccRCC				pRCC (N)				pRCC Type 1				pRCC Type 2
	N	Y-loss	P		N	Y-loss	P		N	Y-loss	P		N	Y-loss	P
ISUP grading
1	176	35%	0.4828		26	96%	0.0027*		24	96%	0.0360*		2	100%	0.077
2	238	40%			85	73%			70	77%			14	50%
3	229	43%			54	76%			23	91%			30	67%
4	50	38%			2	0%			0	0			2	0%
Fuhrman grade
1	32	34%	0.4277		2	100%	0.0581		2	100%	0.6938		0	0%	0.6193
2	375	38%			108	81%			92	84%			16	63%
3	239	44%			53	72%			23	83%			29	62%
4	52	35%			4	25%			0	33%			3	33%
Thoenes grade
1	223	37%	0.4873		35	91%	0.0032*		33	91%	0.0705		2	100%	0.3191
2	393	41%			122	75%			81	83%			40	60%
3	82	38%			10	40%			3	33%			6	50%
Tumor stage
pT1	412	42%	0.157		113	86%	0.0003*		83	92%	0.0039*		29	69%	0.1187
pT2	80	29%			37	68%			26	73%			10	60%
pT3	190	38%			14	36%			8	50%			6	17%
pT4	12	42%			2	50%			0	0			2	50%
Lymph node stage
pN0	100	36%	0.2682		18	83%	0.065		13	92%	0.0325*		5	60%	0.0956
pN1	8	63%			2	50%			0	0			2	50%
pN2	17	47%			6	33%			3	33%			2	50%
Distant metastasis
pM0	80	40%	0.9181		24	88%	0.0009*		20	90%	0.0051*		4	75%	0.2864
pM1	74	39%			8	25%			2	0			5	40%

*P≤0.05.