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. 2021 Feb;9(3):246. doi: 10.21037/atm-20-4898

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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PNGL decreases the interruption of TCA cycle and improves the malate-aspartate shuttle. Ion image distributions of (A) glucose, (B) citric acid, (C) glutamine, (D) aspartate, and (E) N-acetylaspartate. (F) Quantitative data of glucose, citric acid, glutamine, aspartate and N-acetylaspartate in the striatum and cerebral cortex. Data are expressed as the mean ± SD (n=5), scale bar =2 cm. ^##P<0.01 vs. sham group; *P<0.05, **P<0.01 vs. MCAO/R group. PNGL, notoginseng leaf triterpenes; MCAO/R, middle cerebral artery occlusion/reperfusion; MALDI MSI, matrix-assisted laser desorption ionization-mass spectrometry imaging.