Table 3. Top-ten biological functions identified by significant enrichment GO analysis in monkey and human PBMCs after PHA stimulation.
| GO term (biological process) | P value# | DEGs* (2 μg/mL PHA) | DEGs (10 μg/mL PHA) |
|---|---|---|---|
| Human | |||
| Immune responseф | −2.22×10–16 | 12 | 71 |
| Mitotic cell cycle | 3.33×10–16 | 11 | 70 |
| Cytokine-mediated signaling pathway | 3.33×10–16 | 2 | 43 |
| DNA strand elongation involved in DNA replication | 5.55×10–16 | 1 | 21 |
| Interferon-gamma-mediated signaling pathway | 2.00×10–15 | 0 | 26 |
| DNA replicationф | 3.79×10–14 | 4 | 37 |
| Cell division | 4.07×10–14 | 10 | 52 |
| Inflammatory response | 5.35×10–14 | 11 | 46 |
| Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 1.57×10–13 | 0 | 12 |
| M phase of mitotic cell cycle | 4.08×10–13 | 6 | 28 |
| △Phosphatidylinositol-mediated signaling | 4.74×10–5 | 6 | 14 |
| △Chemotaxisф | △1.53×10–6 | 7 | 25 |
| △Mitosis | △4.75×10–6 | 8 | 31 |
| △Negative regulation of caspase activity | △7.21×10–5 | 4 | 9 |
| Monkey | |||
| DNA-dependent DNA replication initiation | 3.30×10–8 | 0 | 4 |
| Immune responseф | 6.29×10–7 | 6 | 9 |
| DNA replicationф | 3.02×10–5 | 0 | 5 |
| Anti-apoptosis | 7.39×10–5 | 2 | 5 |
| Chromosome organization | 0.00016 | 0 | 3 |
| Regulation of cell shape | 0.00017 | 1 | 4 |
| Astrocyte cell migration | 0.00019 | 1 | 2 |
| Positive regulation of cholesterol efflux | 0.00032 | 1 | 2 |
| Chemotaxisф | 0.00070 | 1 | 3 |
| Apoptotic cell clearance | 0.00087 | 1 | 2 |
| △Antigen processing and presentation of peptide antigen via MHC class I | △3.47×10–13 | 5 | 1 |
| △Antigen processing and presentation | △4.07×10–10 | 5 | 1 |
*, DEGs: number of differently expression genes identified by microarray in 2 or 10 μg/mL PHA groups; #, P value for enrichment; △, that means these top-ten GO terms are identified in 2 μg/mL PHA group; ф, the same GO terms used in both human and monkey groups.