Table 6. Overlap DE genes in human and monkey PBMCs after PHA stimulation.
| GO term (P value) | Overlap DEGs (FC: h/m) | UniqH DEGs | UniqM DEGs |
|---|---|---|---|
| Immune response: (Ph =−2.22×10–16); (Pm =6.29×10–7) |
C1QC (0.1/0.4); IL8 (0.4/0.5); XCL1 (2.9/4.9) |
1Mar; C3; C5AR1; CBLB; CCL13; CCL8; CCR1; CCR2; CD274; CD28; CD7; CD74; CD8A; CD8B; CFP; CIITA; CMKLR1; CTLA4; CTSC; CTSS; CXCL1; CXCL10; CXCL2; CXCL3; ENPP2; FCGR2B; FCGR2C; FCGR3A; FCGRT; FTH1; HLA-DMA; HLA-DMB; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; ICOS; IGF1R; IGJ; IGLL1; IGSF6; IL10; IL1A; IL1RAP; IL2RA; IL6; IL7R; LILRB2; LST1; LTB; NCF4; PDCD1LG2; PPBP; PTAFR; RGS1; SAMHD1; SECTM1; TGFBR3; TLR1; TLR2; TLR4; TNFRSF4 | CCL11; CCL18; CCL2; CD40LG; LOC714964; SERPINB9 |
| Inflammatory response: (Ph =5.35×10–14); (Pm =0.00095) |
CCL2 (0.2/0.2); IL8 (0.4/0.5) |
AIF1; AOAH; APOL3; C3; C3AR1; CCL13; CCL8; CCR1; CCR2; CCR3; CD14; CD163; CLEC7A; CXCL1; CXCL10; CXCL2; CXCL3; CYBA; CYBB; GGT5; IL10; IL1A; IL1RAP; IL6; LY86; LY96; MGLL; MMP25; MS4A2; NFAM1; NLRP3; OLR1; PTAFR; RXRA; S100A12; S100A8; S100A9; SERPINA1; SIGLEC1; STAB1; TLR1; TLR8; TNFAIP6 | CCL11; CD40LG |
| Chemotaxis: (Ph =1.64×10–8); (Pm =0.00070) |
CCL2 (0.2/0.2); IL8 (0.4/0.5) |
C3AR1; C5AR1; CCL13; CCL8; CCR1; CCR2; CCR3; CMKLR1; CX3CR1; CXCL1; CXCL10; CXCL2; CXCL3; CXCR3; ENPP2; FPR1; FPR3; PLAU; PPBP; PTAFR; S100A8; S100A9 | CCL11 |
| DNA replication: (Ph =3.79×10–14); (Pm =3.02×10–5) |
MCM6 (4.6/2.9); MCM3 (2.8/3.0); MCM7 (3.1/2.5); MCM4 (4.0/3.5); PCNA (4.4/2.8) |
BLM; BRCA1; CDK2; CENPF; CHAF1A; DBF4; DUT; GINS2; GINS3; GINS4; LIG1; MCM2; MCM5; MCM8; NASP; POLA1; POLA2; POLD1; PRIM1; PRIM2; RBBP7; RFC2; RFC3; RFC4; RFC5; RMI1; RPA3; RRM1; RRM2; TK1; TOP2A | |
| DNA–dependent DNA replication initiation: (Ph =1.25×10–8); (Pm =3.30×10–8) |
MCM6 (4.6/2.9); MCM3 (2.8/3.0); MCM7 (3.1/2.5); MCM4 (4.0/3.5) |
CCNE1; MCM2; MCM5; POLA1; POLA2; PRIM1 | |
| Cell division: (Ph =4.07×10–14); (Pm =0.13773) |
CDC20 (3.4/4.2) | 10Sep; ANXA11; AURKA; BIRC5; C13orf34; CCDC99; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CDCA8; CDK1; CDK2; CDK6; CENPF; CENPH; CEP55; CKS1B; CKS2; DSN1; FBXO5; HAUS1; HAUS4; HAUS8; KIF11; KIF20B; KNTC1; LATS2; LIG1; MAD2L1; MASTL; MIS18BP1; NCAPD2; NCAPD3; NCAPG2; NUP37; NUSAP1; OIP5; PTTG1; SKA2; SMC4; TIMELESS; TIPIN; TPX2; TUBA1B; TUBB; UBE2C; UBE2S; ZWILCH | |
| Mitosis: (Ph =1.13×10–7); (Pm =0.10771) |
PLK1 (6.9/2.5) | AURKA; BIRC5; CCNA2; CCNB2; CDK1; CDK2; CEP55; HAUS1; HAUS4; HAUS8; KIF11; KIF22; KIF23; LATS2; MAD2L1; MASTL; MIS18BP1; NCAPD2; NCAPD3; NCAPG2; OIP5; PKMYT1; PTTG1; SKA2; TIMELESS; TIPIN; TPX2; TUBB; UBE2C |
FC, fold change; Ph, P value of human; Pm, P value of monkey; h/m, human/monkey.