Table 7. Top-ten biological functions identified by significant enrichment GO analysis in monkey and human PBMCs after LPS stimulation.

GO term (biological process)	P value#	DEGs* (2 μg/mL LPS)	DEGs (10 μg/mL LPS)
Human
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIф	0	11	13
Interferon-gamma-mediated signaling pathway	1.11×10–16	14	23
Immune responseф	3.33×10–16	32	53
Cytokine-mediated signaling pathway	1.11×10–16	19	33
Chemotaxis	1.11×10–11	13	21
T cell co-stimulation	5.18×10–11	11	16
Inflammatory response	1.58×10–10	17	2
T cell receptor signaling pathway	2.89×10–9	11	15
Innate immune response	9.11×10–8	13	23
Platelet degranulation	3.13×10–7	6	13
△Phagocytosis, recognition	△2.60×10–6	3	3
△Positive regulation vascular endothelial growth factor production	△1.08×10–5	4	5
Monkey
Antigen processing and presentation of peptide antigen via MHC Class I	−2.22×10–16	13	13
Antigen processing and presentation	0	22	23
Immune responseф	8.88×10–16	30	33
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIф	2.83×10–9	6	6
Chaperone-mediated protein folding requiring cofactor	0.00015	3	3
Sarcomere organization	0.00028	3	3
Positive chemotaxis	0.00061	2	3
Cellular iron ion homeostasis	0.00092	0	3
Aerobic respiration	0.00148	1	2
Antigen processing and presentation of exogenous peptide antigen via MHC Class II	0.00148	2	2
△Electron transport chain	△0.00017	4	3
△Translation	△0.00125	9	8
△ATP synthesis coupled electron transport	△0.00150	2	2

*, DEGs: number of differently expression genes identified by microarray in 2 or 10 μg/mL LPS groups; ^#, P value for enrichment; ^△, that means these top-ten GO terms are identified in 2 μg/mL LPS group; ^ф, the same GO terms used in both human and monkey groups.