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. 2021 Feb;9(3):234. doi: 10.21037/atm-19-4738

Figure 2.

Figure 2

Hyperglycemia affected Cx43 expression in HUVECs and cell adhesion. Normal HUVECs (N) were pretreated with high glucose (30 mM, 7 days) (N + G). Correspondingly, GDM-HUVECs (GDM) were pretreated with reduced glucose (5.6 mM, 7 days) (GDM-G). (A,B) Expression levels of Cx43, ICAM-1, and VCAM-1 proteins in HUVECs under hyperglycemia (N + G and GDM groups) and normal glucose (N and GDM-G groups). (C) Cell adhesion in the N, N + G, GDM, and GDM-G groups. In all experiments, data are presented as mean ± SEM; n=9, *, P<0.05 vs. N; #, P<0.05 vs. GDM. Scale bar in C: ×200 and ×400. Cx43, Connexin 43; HUVECs, human umbilical vein endothelial cells; GDM, gestational diabetes mellitus; ICAM-1, intercellular cell adhesion molecule-1; VCAM-1, vascular cell adhesion protein 1.